Tighter quench, more efficient combustion chambers, optimum compression ratios for the octane, and very well chosen camshaft will require LESS fuel and timing to make best power.
Couple of years ago I built a 455 for my Ventura. It was very tight quench, exactly zero deck, good flowing heads, well chosen cam, etc. It went on the dyno and cranked out 455.4hp and 540tq, and only required 30 degrees total timing to make those numbers. That engine was used as part of the High Performance Pontiac and Popular Hot Rodding articles for the KRE aluminum head testing.
A customer of ours set out to duplicate that engine, used the exact same heads, cam with the same .050" specs but "modern" lobe profiles, same stock iron intake, q-jet and HEI. He took that engine to the same dyno and made 390hp, 499tq.
Turns out that his attempts to "duplicate" our engine came up a bit short, simply because he failed to follow the "recipe" exactly and just figured a little extra quench and "modern" cam with less seat timing but more lift would get the job done.
I was lucky in this deal as very early on I used .020" steel shim head gaskets on all of my SBC engine builds simply because that's what was there when I took them apart. The "rebuilder" gaskets are much thicker, usually around .040-.060" and they lower the compression close to half a point and increase quench distance at the same time. Nearly every single SBC engine that gets "rebuilt" will have the pistons pretty far down in the holes at TDC and a thick head gasket on it. Folks come up considerable short on engine power all the time with that deal, even following engine builds they read about in magazines and on line, and never know why more times than not they don't make the grade.
I've also had some in here to tune that ran pretty hot and sensitive to low octane fuel when they shouldn't have, mostly because they simply had WAY too much quench in them.
Thinking back the worst one we worked with here was a Pontiac 400 with "builder" pistons that were nearly .040" below the deck at TDC and it had really thick Detroit head gaskets on it. Although the compression ratio was only about 9.3 to 1, it ran hot, overheated and POUNDED like sledgehammers with any attempts to put some timing in it to make acceptable power. This was quite a while ago and early in my learning curve so it took me a while to figure it out.
We ended up pulling that engine and replacing the pistons with a much better flat top design with 2 valve reliefs, zero decked it, .039" thick head gaskets, then a cam with 10 degrees more duration to compliment the new compression ratio just over 10 to 1. The result was an engine that idled better, didn't even think about running hot, overheating, pinging on pump gas, and it would literally tear your head slam off when you went to full throttle! It literally felt at least 100hp stronger than before, yet same CID and head flow.
No need to mention how thrilled the owner was with the end result, and we once again educated ourselves as to how important these things are when it comes to building engines.......Cliff