I'd run smaller tipped metering rods unless the primary jet size has been increased some. The Super Duty 455 carburetors use a pretty large bleed tube, and secondary bleed holes beside them. They typically enjoy pretty small tipped metering rods for best results.
Since they were emission calibrated, and somewhat lean on the primary side, it's common to find larger than stock jets in them from folks helping them out some over the years.
In any case, the best way to tune the carb, is to get it perfect on the primary side first, best throttle response, off idle smoothness, fuel economy, etc. Then go after the huge secondaries for best performance at full throttle. If you can find good traction, a couple of dragstrip runs will point you in the right direction......Cliff