High vacuum pulls fuel from the transfer slots in that range, so most likely it will not lean back up until the vehicle slows and some load is put back on it.
The best way to tune with an A/F meter is to put a piece of black tape over it.
Then tune for best results in all areas.
I like to tune WOT at the drag strip with ET/MPH.
Idle is easy, best idle quality at the leanest settings you can manage with the mixture screws. This is done by turning them in until the engine just slows ever so slightly, then back 1/4 to 1/2 a turn till it just smooths back out/highest RPM.
Light part throttle done with the APT to provide best power in the "normal" driving range and best fuel economy. That deal can be difficult if you are a "lead foot" like me, because with over 550hp on tap it's IMPOSSIBLE to run thru a tank of fuel without quite a few full throttle blasts!.
Heavy part throttle is done with jet size only.
You can also tune light part throttle with the vacuum advance, so don't forget that it is a BIG player in engine efficiency in the "normal" driving range.
When you get the carb all dialed in, remove the black tape, you now have the base settings that your engine likes/wants and is happy with.
I've learned over the years that trying to go lean with the APT your primary jet/rod combo's typically doesn't work well as lean settings require increased throttle angle to achieve/maintain vehicle speed so the carb automatically adds fuel to compensate.
It's also difficult, actually damned near impossible to get past the basic laws of physics with these things.....it's going to take "X" amount of BTU's to move a specific MASS from point A to point B......hope this helps some.......Cliff