Thanks y'all! Sounds like it might be a better idea to build one off to the side in anticipation of a cam and heads combo later on. I went ahead and ran a tank of E85 to tinker with, and it runs surprisingly well, it had a bit of a lean pop at cruise but that was it, which I think I could adjust for with a power piston spring change.
I did notice that it wanted to sit and warm up before driving anywhere, it didn't like moving until you start getting some heat into the engine. That's with a Pontiac 350 that has around ~9:1 compression.
Cliff, the parts I am running in the carb now are from you, that 72/42B combo seems pretty spot on for a bolt on Pontiac. I honestly don't know that I could squeeze any more power out of it, just needs some fine tuning on the air door now. As always, your input and knowledge are much appreciated!