I set them to where the thickness of the adjustment "wire" bottom edge is flush with the gasket surface or top of the baseplate. That will get you on and running, then fine tune if as needed once the vehicle is placed in service.
You can also do a "tip-in" test with the engine set to apprx 2000-2200rpm's, but all final testing should be done by driving the vehicle to achieve the best transition, smoothness, power, throttle response and fuel economy.
You are adjusting the part of the carb where you spend most of the time (light engine load) so it may take several tanks of fuel to nail down the best settings........