In all cases, with idle mixture screw adjustments, verify the initial timing setting first. Make sure that the timing is not moving around at idle speed as well. If you have an auto trans car, have someone place it in gear to verify that the timing is rock steady at whatever you have it set at.
If you are using ported vacuum to the advance, verify that it is not adding a small amount of timing by pulling off the hose to the vacuum unit.
Once fully warmed up, and well heat soaked, set the idle mixture screws for the best idle quality at the leanest setting(s).
If the manifold in is dual plane, and fully divided with a fully divided gasket, set each mixture screw out for maximum idle rpm, then trim then in one at time until you get a speed changed, then back out about 1/2 to 3/4 turns. If an open gasket is being used, same procedure but you may have to spend some additional time balancing out the mixture screws for your final settings.
Keep in mind that a lean mixtures is often very "stinky", as quite a bit of unburnt fuel makes it out the tailpipes when we don't put in enough fuel for complete combustion. This is often confusing for many tuners, as they think the mixture is too rich. In any case, the engine will tell you what it wants, and in any and all cases, set the mixture screws for the best idle quality no matter how many turns in or out they end up at.....Cliff