No modifications needed. Keep in mind that you have limited cfm on the primary side with all spread bore designs.
So basically you can not achieve nearly the engine power or vehicle speed as you could with a larger square flange type carb on the primary side alone.
Q-jets and Thermoquads are both very similar in power characteristics and when set up correctly they will provide a "seamless" power curve from idle to the shift point.
Folks seem to expect some sort of "rush" of power with 4bbl carburetors which is actually a loss in performance if you have noticeable transition.
Since the Q-jet provides air to the engine based on demand, set up correctly you will not feel any "rush" of power going into the secondaries. Since you don't feel any "hit" or transition the body will evaluate the performance as less than a carb that feels like you just hit the nitrous button!
So when set up correctly you will end up with a broad/flat power curve with no noticeable transition anyplace. The "boring" power curve for sure will be thought a loss in power performance if evaluated by "the seat of your pants".
I've tested more carburetors back to back at the track than most who will read this. One event in particular we tested 8 carburetors on two very fast cars in one day. One big Holley, one big Edelbrock Thunder series AVS, and 6 Q-jets. The carburetor that is on my car currently won all testing, 60', ET and MPH at every point. It did this on both vehicles. With that said if you raced the car with the Q-jet in place, then the big Holley double pumper we tested, you'd very quickly say that the big Holley would win out in every area. This simply happens because the Holley provided a HUGE "rush" in power when you got into the secondaries, the Q-jet was "seamless" clear across the load/speed range.
Here is a clip of my car a the track in full street trim. Notice how smooth the power comes on and stays in the power clear down the track. No big "rush", no lunge, no noticeable transition anyplace......Cliff
https://www.youtube.com/watch?v=6zVdoLR-VzM