It is hard to say for sure with out a dyno, but I would be willing to bet it has an affect on it. You could use a 4 hole spacer and cut and grind on it. Opening it up as much as you can, then use a grinder to blend it to the manifold opening.
I did something like that years ago. Some epoxy to seal as well as possible because of the amount of cutting I did, and blended an open center spacer to a single plane intake. By the time I was finished you would have believed it was an original quadrajet single plane.
Or you could sell it and buy a RPM quadrajet manifold.
What are your engine build specs that you need an Eddy RPM? Just a zz4 cam and ported heads? I thought the zz4 came with the GM bow tie quadrajet intake?