Tune for results not what a gauge is showing you. If you are lean to a point where the engine doesn't like it, at light throttle for example, the engine will surge, lack power, "flat" with a little throttle movement, or even backfire up thru the carb if it gets way too lean. So basically in certain scenarios you may see really lean on a gauge but the engine load is light enough it doesn't care.
Every engine has slightly different requirements across the load/speed range but most will like similar numbers as a general rule. Don't forget about ignition timing, especially the amount added by the vacuum advance. It is a load sensing device and designed to add timing when engine load is light and engine vacuum is high. This allows us to burn a much leaner mixture all else being equal, so don't forget to use it as part of your tuning......Cliff